In the last issue of "Venom", Eddie Brock warned the main superheroes of the Marvel Universe that the Maker (Ultimate Reed Richards) could lead an invasion of 616's Earth with the rest of the Ultimate Universe. I'm pretty sure not all the characters from his Universe will side with the Maker; as some of them MIGHT join voluntarily while others will be submitted by mind control or something. Some Ultimate characters will definitely side against the Maker, and that's why I put this threat here. I'm quite sure between the ones who will side against the Maker will be Ultimate Peter Parker and his supporting cast.
Now, how could this affect 616's Peter Parker/Spider-Man. We already know 616's Peter Parker visited the Ultimate Universe and that's when he met Miles Morales for the very first time. His counterpart was dead by then (or at least we THOUGHT he was dead), so it would be interesting to see these two Parkers interact with each other for the first time. Pretty sure Ultimate Peter could put his beloved ones at safety first (like his Aunt May, his Gwen Stacy and his Mary Jane), and 616's Peter would be glad to see them again.
It would be interesting if Ultimate Gwen Stacy and Ultimate Mary Jane meet their counterparts in 616's universe too. Well, in Gwen's case, her "Spider-Gwen" counterpart. So, how do you think this event will affect Peter?