Spoilers if you haven't read ASM # 60 yet



At the end of Superior Spider-man second run, Mephisto offers Otto Octavius a deal to restore him to his former self in full health, effectively removing the Peter Parker portion of his cloned body, and presumably the moral compass, if there was one, that guided Otto's decisions. Mephisto seemed to downplay Parker's contribution to the Superior identity, but it seems clear that Otto accepting the deal played right into his plans.

Flash forward to ASM #60 and Doc Strange's query to Mephisto and what's wrong with Peter Parker's soul and I'm wondering if any relationship between these two events will be revealed, or is the Mephisto reveal just a red herring. It's possible Mephisto was satisfied with the OMD deal and delights in the constant resets in Peter's life. On the other hand, he seemed eager to rid the portion of Peter in Superior Spider-man.