Scott and the Champions I think was one?That's dark. I think people forget mutants can give birth to humans. I honestly feel that is the best way to finally address the issue when it comes up on Krakoa. I just don't think anyone is in a rush to get there. I actually feel like it would be a cop out to say humanity simply stops existing as they were because in life someone is always left behind. And even in terms of the marvel universe even by 2099 if it were to happen humans should still be being born unless they purposely try to breed them out which would be dark and just wrong imo.
But then i guess it has been addressed in the swense shogo is human so it's evident mutants don't hate humans so that's what makes it different. With Kyle and shogo there it's not like mutants want to actively get rid of humans or even hate them so... yeah
and now really thinking about it even if in universe can people really say the avengers are friends with mutants. I'm really trying to think now and i've seen Cap visit tchalla, show up to help same with carol and tony, all in their own books but aside from the she hulk scene with logan and pretty much only scenes with logan i can't think of a scene where these heroes went and checked in on their "friends"