Even the main universe has reused the registration from Civil War to Outlawed, and a lot of that stuff was done to keep the X-Men stuck in a corner, or if allowed to come out and play only to prop up other franchises. But those are all just writing choices. They could have easily gone back to pre-hysteria days or pre-decimation days and continued on building up mutants as the next step of humanity and had society as a whole accept it. The only argument against that is "Moira" which is a fabrication purely to justify what Hickman is doing. Having mutants on an island is not going to stop them from going through the same crap unless writers stop, and if writers stop then mutants could be anywhere.