In my own mind, it would be mostly the other way around, with a bit of crossover between certain characters.

although they've always been considered explorers, I rather like some of the stories where they fight the evil FF or various other villains as well as some space opera.

Some of the stories were both, like right after # 200, when they began an Andromeda-Skrull war with a number of other cast members and the aging ray on 3 of the FF was slowly ticking their lives away.

But I think you mention key characters who should be involved and this would help the overall viability of the comic (Foundation) but also provide character arcs.