This is something that I would love to see explored. I'd love to have Mayday Parker appear in the main universe like Peter goes on a time travel adventure changes one thing and when he gets back he finds that he shares custody of a teenager with MaryJane. I just love the possible shenanigans that would insurance from something like that especially if she was more like her Mom didn't get along with Peter until getting powers like him. I also love the idea of there being a parallel with Peter like her lying to him about going somewhere and somehow MJ or someone else gets hurt because of it.