I can see it be a big line, where each version of Kang wages an attack on one of the different corners and groups of the Marvel universe. Maybe instead attacking the main timeline they attack in the past to change things to ensure their victory. Those with time connections then get teams to deal with the appropriate Kang.
In Comics, the last "Big" Kang storyline I recall reading was in the first arc of Waid's run. I didn't deslike it, but it sure didn't excite me as much as, say, Avengers Forever or Kang Dynasty (the event mentioned by Charlie_1981, which, truth be said, had a LOT of it's impact neutered by editorial when they decided to make it a self-contained "event". Still one of my favorites, though). Maybe it was the art. Not a huge Del Mundo fan. But the fact is, it didn't feel impactful enough. And Waid is what I consider an old school writer. With the exception of Al Ewing, and maybe not even him, I can't imagine any other current Marvel writer that could give us a decent Kang time-spanning epic.
Peace
Wasn't there a pretty long Kang arc during Waid's All New All Different?
It's the story I mentioned above. There was a subplot that went on through All-New, All-Different, with the proto-Champions, and that culminated in the first arc onf Waid's mostly adult Avengers, with art by Mike Del Mundo, in which Cap erases the past of the then active Avengers (Falc-Cap, Vizh, Spidey, Nadia-Wasp and Thorette - Jane Foster), except fot Herc, which he fails to determine the date of birth due to unprecise records. The Avengers than face multiple versions of Kang with a couple of multiple versions of themselves (current line-up + original line-up + Stern's late line-up). My summary actually sounds more exciting than I found the story itself to be. Good ideas that just weren't developed as well as, IMHO, they could have been. As I said, I didn't dislike it, but it didn't wow me much.
Peace
There was one with the post-Hickman Avengers where he possessed Vision to prevent the Avengers from assembling.
Waid followed it up with the Avengers post-Champions leaving where Vision takes revenge by attempting to assassinate Kang when he's child and the Kang variants get involved.
"Cable was right!"
with Kang, how do you avoid the conceit of "another one" just immediately showing up after the most recent guy is sent back/defeated, etc.?