I don't see why the Spider Family wouldn't exist? Mayday, Ben, Miguel, Kaine, Jessica, Julia, and Anya all already did exist before 2009, and Silk, Miles, and Gwen would still have happened, Miles was created when Bendis decided to kill off Ultimate Peter, and the other two were created for the Spider-Verse event.
Amazing Spider-Man 3 probably would've happened, yes. Doesn't mean they'd have continued indefinitely though.
Fant4stic 3 would never have happened anyway, Fant4stic was a failure. It still wouldn't have got a sequel even if Disney didn't buy Fox or Marvel wasn't owned by Disney.