One complication is that some fans are lunatics.
We hear about death threats over events involving fictional characters. How will those fans react to actual life and death issues? Ultimately that's what political discussions boil down to.
In addition there are some taboo issues. For many people it doesn't matter if you're right about the facts if they sense that you're on the wrong side of an issue. This complicates the reception to comics, tv and film. Comics and TV are also serialized media where you don't know where a story is going, which may also lead to people panicking about potential plot points that will never happen.