I'd like to see Peter involved in an organized crime task force with the police department. (in MC2 Spider-Girl's world, Peter is a CSI supervisor in NY, yes?)
Concurrent with that, similar to "the shadow", Spider-Man would have a network of informants who do not know his secret identity, but who share with Spidey their knowledge on various goings-on in New York City and the near vicinity.
Spidey can take advantage of the abandoned subway stations. Like in the Andrew Garfield films, he can set up a 'spider-cave' base in one of these. Not necessarily Reed Richards tricked out, but enough basic laboratory stuff to do what Peter can do, without nosy neighbors wondering why he always gets large deliveries of chemicals (for web fluid, of course).
I'm interested in Peter seeing other people besides MJ, who can still be a consistent friend.