I’d assume that the Mutants, Avengers, Deviants and Rebel Eternals will need to stop Thanos from being permanently Jones to the Machine, because of anything is likely to get Earth destroyed it would it become the means of Thanos getting full immortality
They aren't all heroes, but if I give your argument the benefit of the doubt, that they are heroes, then their civil war can be a disagreement. A civil war is what comic fans/companies call it. The first civil war event at Marvel was someone thinking someone else's measures were authority run amok.
Anyways, mutants against mutants is like humans against humans. It's not an issue if it's amongst themselves. It's just to shake things up a bit.
YOu know more than Omega on Omega I wonder if non Omega can stadn a chance. What they will do to even the field? Using cybernetic Enhancement perhaps? Undergo same empowering process as Luchino Nefaria(really funny thing in MU is that there is veritable, pretty much relaible procedure that can grant kryptonian level of Power and....it was used just once because?)? A bath of Gamma or Cosmic Radiation(albeit in the times it happend it did had some weird effect on Mutant biology...)? Symbiotes?
Still I get Bio-Shock vibe from all this....
"All good things flow to Krakoa....
now...would you kindly....OBEY!!!"