Also the dynamic between Wanda and Chthon did change vastly.
spoilers:end of spoilers
Before, Wanda is the defiant investment of Chthon, she is valuable to Chthon even though she didn't really want to cooperate.
Now she is more like a pure obstacle to Chthon, he and Chthonic factions will probably straight up want to kill her now instead of trying to capture her and use her.
One of the interesting storyline that can come out of this is Wanda watching out for Chthon's "backup plans", which involve other characters with Chthonic connections, namely Victoria Montesi. Or maybe even help them finding a "cure" like she did.