Wild pull, but I'm not opposed to it. It doesn't even negate the possibility of the loose events of the comics or the show happening in the future. Nico would presumably be 15 years old like many American highschool freshman, and any revelations about her parentage wouldn't be until she was sixteen. It also isn't unusual for a rich high school student to go away for school. I cannot say for true if this will be accurate to the comics or show Nico, but with everything we know thus far it is certainly plausible.
As for the supposed incongruities with the MCU, the Marvel Universe has enough plot coupons to remedy just about all of them. Nerds are just impatient.