Man what type of new villains do you want?more adventures outside of New York City. I wouldn't mind a road trip arc like what's planned for Steve Rogers. But I suppose that would probably end up in a separate mini series.
a more stable job that's not going to get yanked from under him in a bizarre, convoluted way.
Either he's making progress in his academic life or just leave it alone. No more plagiarism scandals.
Peter is more respected among his peers, not privately looked upon as just a goofball. Same goes with Spider-Man and his superhero peer groups.
A more reliable police connection. There's no more Watanabe, and no more Jean DeWolff. I have someone in mind, but I'll leave it alone for now.
An expanded social circle. New characters who actually last for a while. Plus some vintage supporting folks who usually have disappeared.
New villains. new villains. new villains. I'm not that interested in the latest super-scheme of Dr. Octopus; I'm not interested in returning him to "Superior Spider-Man" at all. I'm also not interested in any clone shenanigans. Ben still exists? Fine. That's it. I'm not interested in Kaine or the 12 other clones that are floating out there.
I'm not interested in symbiotes. Flat out. I can't keep track, and the choice to make Brock/Venom nothing less than a cosmic status force is... again, I'm leaving it alone.