I'm 99% sure that Luke Cage will become the Mayor of New York at the end of Devil's Reign, which could lead to a new ongoing for him.
As for the Kingpin, I see two possibilities.
The first is that he is arrested / dead / defeated / on the run, but leaves a huge mess behind him for the heroes to maneuver around.
The second (which is less likely) is that he ends up as the President. This was sort of floated as an idea at the end of Devil's Reign 1.
It really depends on whether Chip Zdarsky believes there is any more juice to be wrung out of the 'Wilson Fisk in charge' idea.
Either way, his days as the Mayor of New York are nearly over. That story has run out of steam.