Responsible for the Osborn "curse" and sending Harry spiraling into madness and death. Responsible for putting Norman Osborn in a place where he could be anything other than a pathetic broken man with little money to his name and terrible father. Like headcanon away all this as much as you want but Harry's been pretty much his unknowing stooge for his entire life and Norman would be nothing without him. Undoing Doc Ock's redemption arc. Destroying Spider-man's marriage and unmaking his child. Sending children cloned by Gwen Stacy after Peter. At this point, he's beginning to feel more like the Arch than anyone else.