This sort of stuff throws me, too.
Spider-man doesn't live in a Loony Tunes cartoon. The universe has to have some consistency and rules for it to work and this stuff immediately takes me out of the experience.
We're at the end of a redemption story about a guy who almost destroyed the world rediscovering what it means to be Spider-man. He's trying to restore his sense of heroism and self worth, as well as reconnect and reconcile with those who have been important to his past.
Furthermore, he's working for an evil corporation whose goal is to corrupt the notion of a hero, create their own villains and monetize the skirmishes between the two while also using them to cover their shadier business practices. They are actively altering Ben's very mind, a horrific thing to do to a guy specifically trying to regain his identity, to make him their puppet.
In the same issue (we believe) the company has mutated one of their own employees, Ben's friend, into a mutated Lizard/vampire hybrid because he failed them.
An evil sandwich does not fit. It's so ridiculous that it breaks the 4th wall for me.
Honestly, this series has been weirdly light throughout considering the concept and themes behind it. I get that comics can just be fun nonsense and that's fine. If a man-eating sandwich appeared in Chu I'd be laughing my ass off. Heck, if it happened in Spider-man/Deadpool I'm sure it would work (I didn't read that book, it's not for me).
But this doesn't really work in Spider-man's universe and definitely not in this story. Especially as we're almost at the end.