Jezebel is a very brief obstacle that sets the stage for Bruce's absence, but she of course is despatched by Talia by the half-way point of the run. Morrison's run is all about Bruce falling out with Talia as she began to fully embrace her corruption. It's about one long established and familiar relationship falling apart. Morrison has even said it was inspired by their parent's divorce as a child.
Of course, now the Bat Books seem to finally be trying to patch up Bruce and Talia, so we'll just see what happens.