Speaking of, End of Spider-Verse could be a great opportunity to bring back the Spider Society. Given where things seemed to have left off with their last appearance in Silk's original run by Robbie Thompson, with Tamara Pearson/Fang taking over after Ezekiel's death and trying to steal Silk's powers for herself, it might be good setup for a civil war in the Spider Society. Hell, I'd take bringing back the Spider Society and having them trying to control spider-powered heroes, anti-heroes, and even villains, eliminating (or trying to eliminate) the ones who won't or can't be controlled, over just blowing up the Spider-Verse.