People are going to attack the show anyway for having a non white Velma.
Anyway, if this show fails it won't be because Velma is Indian American and more to do with writing and execution.
There are valid criticisms to be made about the show but I don't think changing Velma's race is one of them.
For me, I don't mind mixing up the formula I remember watching Scooby Doo cartoons from the era where it was just Daphne, Shaggy, Scooby and Scrappy and 13 Ghosts of Scooby Doo. But if all this show has to offer are gore, nudity, swearing and Harley Quinn style humor as it's selling points then it's a pass for me.