Honestly, if they could make Peter in a different relationship work, I'd be all for it. I've always had a soft spot for a What if in which Peter and Sable got together (Ironically it was "what if Spider-Man married Black Cat")
That book aside, I CAN see Peter and Felicia working out since they've both matured since then.
The problem is that Spencer pretty much had them practically married again and so even those who were fine with Peter being with other people want him with MJ.
Though honestly, Felicia and MJ's recent team up show that THEY have good chemistry as well, but Marvel would never go that route.
As for the thread, the main problem is that Marvel HAS shaken up the Status Quo and then, with some exceptions, reverted right back. Pretty much the only thing that's stuck is killing Gwen and revealing who he was to Jonah. I would say getting married, but we see how that turned out.