In the later parts of his run, Stan Lee dealt with issues that were in the news like international terrorism, prisoner abuses and drug addiction. JMS would tackle contemporary issues as well in his run, looking at school shootings, team homelessness, etc. Peter David's Spectacular Spider-Man run focused more on ordinary crime and the people affected than supercrime.

What type of issues would make sense for the Spider-Man comics to tackle in 2022?

There are potential complications in introducing multiple sides of an issue in twenty page increments. Marvel doesn't want to damage a brand by association with controversial behavior, or to be too square.

I think one topic that makes sense is counterfeit pills. Whatever your stance on whether Adderall should be more readily available, it's a bad thing if someone gets it laced with fentanyl.