It was promoted prior to the launch that everyone was on the outs with Peter Parker and that Otto Octavius was gunning for him as part of a master plan. Once the actual volume gets underway, we find...
1. Aunt May gets over her disappointment in Peter by the end of the first story arc
2. Felicia Hardy never stopped caring about Peter, giving him a rooftop pep talk before later attending his birthday party along with all his other friends.
3. Mary Jane doesn't stay mad at him, as she accepts Peter's apology for how unfairly he's treated her and attempts to tell him how she truly feels before she's interrupted by her controlling boyfriend Paul.
4. As for Otto? Instead of being the central antagonist, he's revealed to have been made a prisoner of the Ultra Living Brain in the first issue and used to power the Sinister Super Adaptoid in ASM#900.
Anything else? Or have we all covered the empty promises of volume six?