I honestly love Norman and Doc Oc but after all these years I feel like they've drained the well in terms of stories they can do with them. I mean they mostly use Kingpin for Daredevil these days and he's in my opinion the best enemy Peter has. I think a good villain to give Peter would be someone like Black Mask from DC but with a very close connection to Peter. I figure a new crime lord could be on the rise and flooding the city with drugs and such. I like the idea of Peter trying to step in and getting caught and being told that he killed the guy's dad and learning that the mugger who shot Uncle Ben was the crime lord's Dad. I also would add a Spiderman 3 twist where Peter learns that the crime boss was with his Dad at the time and shot Uncle Ben when they tried to get away and ended up splitting up.
I mean it'd be interesting I think if done right especially if the Criminal shot Uncle Ben not out maliciousness but because his Dad the mugger that Peter chased down screamed at him to the point where the son couldn't take it anymore and the gun just went off. I like that idea because it would parallel Peter causing the mugger to have a heart attack (I think that's what happened in the comics) and the two would essentially have created each other. It'd also be interesting if the new villain saw Spiderman as the problem and saw his actions as changing the city's crime from within.
Also I like the idea of a new villain whose just a standard mobster with a major tie to Peter posing a threat to him. Peter being up against a criminal who can match wits with him would be cool and refreshing compared to the constant battles with the standard rogues. I just love the idea of a bad guy not being a physical threat but having the viciousness, resources, and brains to scare Peter.