I really, really hope it doesn't turn into something dumb like "MJ found weird cloned babies and Peter refused to raise them because he's allergic to clones, that's why she left him and found someone else". I genuinely have no idea what could force her to break up with him or HOW Peter could mess up so badly entire city straight up hates him.
I'm usually really into solving mysteries and puzzles, but this one is more annoying than intriguing. I doubt "it will be worth it at the end" as Marvel promised.