One of the main things that really bothers me is how there was a story arc of Norman having something to do with May Parker's death but rather than have any confirmation of this being true or not May was just brought back. Honestly, I really don't like how that happened and now Peter is just "friends" with Norman now. I use the term loosely, but it does bother me I think a good way to bring her back would be to say that Mongrain gave someone the child behind Norman's back. I figure a good candidate for a stunt like that would be Kingpin he'd likely justify it as both protecting a child from Norman and gaining a potential new weapon against Spider-man.
I think it's possible given in one future Peter has an evil granddaughter that's she's alive. Also, I love the idea of Peter having a Jason Todd of his own who just kidnaps Norman beats him to a pulp and holds a gun to his head demanding to know why Peter never killed him. Also, if Mayday did return, I'd love for her to be the opposite of Peter and just really push his buttons that'd be a nice dynamic for him to have to put up with a bratty teenager and have to deal with nightmares of her idolizing the Kardashians and constantly taking selfies.