All of those sound very good. Especially like the first and third, but Peter and Liz finally getting their shot together so many years after they first knew each other (hopefully having it go a lot better than it did in The Spectacular Spider-Man animated series) would be pretty amazing to pull off. Speaking of the first, I'd go with Carolyn Trainer resuming the Doctor Octopus name and striking out as a reminder of Otto's less-than-positive legacy, spurring him on to make something better of himself that he can leave behind instead.