So I have a prediction on the inevitable DLC/Expansion to this game. I'm going to assume there's going to be another "City That Never Sleeps" style of expansion and based on the ending of this game
spoilers:end of spoilers
It'll be Miles-centered since Peter has decided to go on hiatus. One plot point that was established in Miles' game but wasn't followed up on here was Kingpin trying to rebuild his empire. In the Miles Morales game, one of the side missions saw Miles putting a stop to his attempt to expand into Harlem. So yeah, a shorter expansion focused on Kingpin as the big villain I think would be a safe bet.