I think old old issues of What IF? have Sue as the Thing, a big irony I suppose.
Although many of us have seen or come to see/love the many faceted person she is,
she is somewhat of a pure ( = bland) template for all these
inversions. It's actually pretty cool in a way but
why not have a version of Sue more akin to Spider-Gwen, or the Maker.
A universe's Sue that is different and unique, and capable of becoming a main character like those.
(and not necessarily evil). for example a universe without a Reed, but a just as intelligent Sue
who along with her Avengers discover Captain America in ice.
She eventually marries him.