I was just browsing the April solicits (up on Previewsworld) and they have a listing for a compendium of Remender's "Black Science".
This line in the solicit caught my eye: "the seminal series that launched the multiverse craze".

A bit (as in, a "huge") of a stretch to claim this series started the "craze". I enjoyed the series, but I don't recall it getting the sales or the PR that would lend any credence to that claim.