sooo... in the main universe Pete and MJ had a baby who died, presumably this would have been May Parker.
MC2 had it that May lived, ended up with a cloned sister in April, and a younger brother in Benjy.
Then there's another alt-u where Pete and MJ have Annie Parker.
In Old Man Logan, Pete and an unknown woman had at least 2 daughters, the younger of which was Tonya Parker. Tonya had a daughter of her own. Ashley Barton... ended up being a super-villain, but had at least some of Spider-man's power.
Soo... what others have there been?