Considering that the Maker preferred having a Miles Morales in his universe over a Peter Parker, is already a small win right there.
Ultimately, it will depend on the story Hickman tells - will it be a universe with new characters who rise up since there is no Rogers/Stark/Xavier/Parker/Reed, or will it be a universe where we see altered versions of those same characters. With new characters, diversity can be simply implemented. If is the altered versions, then it'd have to go the Nick Fury route.