Yes. I answered this question in the "when did canon end?" thread, but the comic has been marred by too many retcons since the 90s. Since then, there has been a lot of internal and external conflict over the direction of the series that has dragged the narrative all over the place depending on whoever is at the steering wheel. Just look at Harry Osborn: dead, then alive, and now dead again. This is inevitable with any long running franchise, but is also probably why canon should be rebooted after a certain amount of time.