With the Ultimate Universe in its way to officially returning, I'm quite interested to see more of the Ultimate version of Peter Parker/Spider-Man.
I mean, the last time we saw him was in the "Spider-Men 2", when 616's Miles Morales went to the Ultimate Universe. By the look of it, he was in an official relationship with Mary Jane, his life was stable once more, and it seems his clone (Jessica Drew" had become something like his "sister".
Also, in the promo covers of "Ultimate Universe", one of the shadows behind Captain America, Iron Man and Thor seems to be Spider-Man himself.
There are some plots that were never solved in the Ultimate Universe that I want to see solved, and that's why I don't want this reality being "rebooted", but continue where we left it. For me, the most interesting plot was about Mary Jane possibly not being cured of the OZ that turned her into the DemoGoblin.