I think the Ultimate Spider-man was very much a product of its time. I don't think you can recreate that. If there's another Ultimate Spider-man, I think it really needs to be a new thing.
For when my rants on the forums just aren’t enough: https://thevindicativevordan.tumblr.com/
Yeah it's a new "Ultimate" universe, as the first one is Miles's domain now.
The original Ultimate Universe had some things that came out of the classic sketch: The Green Goblin was a hulking monster instead of a stupid mask, Harry became the HobGoblin, Peter got a female clone (which I think she could be Teresa's counterpart).... The animated Ultimate Spider-Man also got differences from the classic scheme: Harry becoming Venom, Mary Jane becoming Spider-Woman (although I would prefer her without Carnage), Spidey working with a team....
If they are going to try different stuff here too, I would welcome it, as long as they don't go "too further".
I'd also accept Chat as 6160 Peter's LI.
And Tobin could write it.
Actually just bring back Marvel Adventures Spider-Man already!
But in all seriousness, if you want to actually have a Peter Parker Spider-Man who's able to date new love interests and not have the shadow of OMD, this is your chance, Marvel.
Or just up and have a new Spider-Man entirely, go nuts.
"He's pure power and doesn't even know it. He's the best of us."-Matt Murdock
"I need a reason to take the mask off."-Peter Parker
"My heart half-breaks at how easy it is to lie to him. It breaks all the way when he believes me without question." Felicia Hardy