I think a critical part of Peter Parker is that he failed to act on his responsibility and paid the price for it, and that's what inspires him to be a hero. That's a big part of what drives him alongside the core values instilled in him by Uncle Ben and Aunt May. The inherent tragedy of Spider-Man.
But if he never had his powers at an impressionable age he never had that power high or that feeling of superiority before things crashing down. He also didn't have to be a neurotic mess having to juggle so many different things at such a young age. Now he'll have to do it as an adult but also potentially having to juggle even more than he did in 616.