There's a topic like this in the Wonder Woman section of the forum, and I thought it was a fun enough one to bring over here.
So, if you could pull any NON-comic badguys into Marvel to make into regualr Spider-man foes, who would you use?
To get us started, let me toss out three ideas.
Dr. Wily
A crazed old scientist that likes to send out his own gimmicky team of robots is a good enough start, but he's also got his own high tech secret lair. Plus it's be great teaming him with people like Norman and Otto.
Gozer the Gozerian
This is such a New York feeling enemy that if the Ghostbusters aren't in this reality to stop her, I'm sure Spider-man would step right up. (He might want to get some help from Dr. Strange though.) I can also see him making the exact same "Choose or Perish" mistake Ray did.
Krang
Like Wily, he's got his gimmicky tech and his secret lair, but he takes things a step further and more into Spidey territory by making animal themed super villians (or mutants as they're called in his world). I'd also demand a team-up with Arnim Zola and MODOK.