There is barely anything left for him to suffer over. The only thing that really jumps out to me would be Robbie/Randy dying. I guess one of the heroes could die but I don't really see them 'killing' another hero after Kamala was basically announced to be alive again before it was even official that she was dead.
I guess it could be a Norman betrayal, but there is what 5 issues before that happens in 50 so it would just be strange of me to have Norman perform some massive betrayal that isn't really addressed for 5 issues. I guess the 5 issues can be Peter figuring out Norman was the betrayer but then you would have 10 (5 for setup, 5 for goblin arc), dedicated to this which is basically half of the remaining run.