I think there is too much legal stuff involved with Amalgam to do it again tbh
But if they did I'd like to see combinations of Cassandra Cain and Laura Kinney becoming Laura Cain the Dadk Talon and Stephanie Brown and Gwen Stacy (Spider-Gwen) becoming Stephanie Stacy the Ghost Spoiler
Miles Morales and Virgil Hawkins, Virgil Morales aka Sting