I think Uncle Ben's opinion on this can have two sides.
- On one hand, he could think Peter is acting irresponsable because, as Spider-Man, he might be putting his wife and children in danger.
- On the other hand, Uncle Ben knows the world is a rotten place with many secrets hidden from the public, so Peter fighting against all this could be the help Ben and Jonah needs to uncover the secrets of this world. On this, Uncle Ben would be proud of his nephew.