I think it's way too early to tell; for one thing, we need to see if the series continues to do well or if this's just the honeymoon period. If it continues to do well, it might continue to normalize Peter Parker being a father as a "default" status quo and add a little more weight to the point that the marriage is way more popular and wanted than Marvel suits seem to think. All that, though, depends on how well the series fares and what the content creators at Marvel and their business partners choose to do with it.
Dan Slott thinks it's doing well and I think he'd be the first to say if it wasn't (presumably to head off any arguments that the series proves that fans want the marriage back, if that makes any sense). Beyond that, the multiple printings is encouraging.