It's so difficult for me to care about anything headlined by the Trinity. I have to imagine a lot of other heroes will be involved though.
Since the Trinity are front-and-center, I have to imagine they'll figure out how her plan to steal "powers" might or might not work on heroes without powers (Batman) or aliens (Superman) or mystical-based heroes (Wonder Woman) as well as heroes whose powers are tech-based (GLs etc) rather than using the easy meta-gene plot device. I also hope they don't ignore heroes who should play a bigger role just to make sure it's Trinity focused. With Waid, I feel there's a decent chance we'll see some random heroes get a spotlight.