What if Peter Parker was bitten by a radioactive cockroach?
What if the Beyonders were the cosmic equivalent of LSD and Secret Wars was just one massive acid trip?
What if Ultron and Master Mold joined forces with the Decepticons?
What if the Asgardians, the Olympians and every other pantheon of Earth gods were all created by Mephisto? (And by "created," I mean that he took proto-humans and some sentient animals, granted them preternatural powers and told them to gather worshipers whose faith would ultimately empower him.)
What if Thanos fell madly in love with Oblivion?