Ever since Robinson killed off Wesker for no good reason, there has been a reaction against the character and a lot of criticism listing him as a lame character.
I can grant that it would be incredible hard to pull him in a movie, but I think even that could be achieved. Along with the some portrayals of the Mad Hatter, he is a symptom of how low has the Gotham underworld fallen. When one of the crime bosses in a big mobster war uses a freaking puppet as an avatar for his dual personality, it pretty much means havoc reigns.
The idea is not that bad, a criminal genius trapped in the body of a meek. He can be played for laughs or as a threat that at some point looks ridiculous.
One big problem I have seen with the character is that sometimes artists go too far with the puppet. The original was kinda odd, and the recent ones look too much like some cheap 80s horror movie. I think the first BTAS version was perfect and timeless.