Alex and Maddy: for Sci-fi space stories Cosair/Vulcan/Shi-ar, for magic horror the Limbo, Goblin Queeness of it all, there are the complicated issues with Cable and Stryfe on Maddy's side and possibly even more complicated issues with Scotty (Alex and Maddy's kid Mutant X alt universe) and Katherine Summers (Alex and Wasp's kid in an alt universe, hey he is a Nexus being) on Alex's side when it comes to the kids. They both probably have major issues with the Marauders as well, Greycrow uh-oh and have a secondary beef with Apocalypse since he is Cable's sworn nemesis depending on ever changing canon. Throw in a little Val Cooper liason to recognized government of Limbo and you have an ongoing that can go at least 50 issues.