I am sure just like previous events that there are going to be new titles after Original Sin. Given that alot of the books rebooted for the NOW! initiatives are of high quality I would be excited to see the following titles.
Black Panther-Hickman or Abnett and Deodato
Deathlok(so overdue for this) Perkins and Remender
Dr. Strange-no idea for writer, Pagulayan for art
Eternals- Lee Weeks and Pak
Namor-Brubaker and Epting
more as I think of them lol