I actually rather like both Pretty Deadly and Shutter. As FHIZ said, Pretty Deadly will be back but it will take some time. I've heard some folks call Pretty Deadly pretentious, which I do not see personally any more than some Vertigo titles mentioned in this thread. Shutter, to me, gets better with each issue. It started off a little bit average but I think the first arc has been pretty solid and will continue to buy it.
As for other newer talent, check out Sheltered. That book is incredible and will be ending with Issue 15. It has some great characters and one of the best villains in comics, in my opinion.