I am also surprised that we have yet to see an alternate reality Spider-Children, such as the daughter of Spider-Man & Black Cat(Next Avengers) who would have beaten some sense back to her mother's evil 616 counterpart.
In addition to Spider-Gwen, wouldn't it had been cool to have seen an alternate reality Spider-Woman whose real name was Natasha Romanov(bitten by the same radioactive spider on her spy mission as Madam Natasha)? Afterall, there is a Spider-Man whose identity is Dr. Bruce Banner. I wonder how a Spider-Woman version of Natasha Romanov would do, alongside her Black Widow military training and fighting skills?