Easy. 2010. Any other answer is wrong.
We lost the marriage in 2007, but there were other good stories that year. 2008 was fun, 2009 looked promising, but 2010 disappointed on all of the year before's promises. The boring Carlie relationship, that woeful piece of crap OMIT and then the lackluster Origin of the Species. The book then became Marvel team up for the rest of the year. Few trades out that year, too. Not an awful year, I can find some Spidey goodness in every year he has been out but 2010 certainly had the least.