I think Wonder Woman's arch-nemesis is an empty chair, right now. That said, her perennial sorceress enemy, Circe, is slowly developing into something interesting, outside of the WW comic.
The new Circe, according to Justice League Dark, was a heroic sorceress princess, whose people married her off to a tyrant, to make peace between their kingdoms. When she killed him for abusing her, the tyrant's family demanded justice, and her people chased her out of her own land. Outraged, she sailed the ocean, until she came to an island, where she made a pact with Hekate, who gave her cosmic powers - powers she used to punish her people, upon her return. I guess she became a cosmic being...after that?
I don't know.
JLD kind of blurs things, from there, ..but, when she shows up, thousands of years later, and tries to conquer the world of magic, Wonder Woman stops her. In "Withcing War", it's not clear exactly what threat Circe is to mankind (what she wants from all of us), but, she puts a pretty creepy bunch, together - like the Upside Down Man - who raid the Hall of Justice for mystical artifacts. She wears Turkish-influenced, Northern Greek dress, and her hair is on-fire, ..but, it's a great story!
So...what this has to do with hating Wonder Woman, I don't know, but, it was a page-turner, and Circe was smack in the middle of it. Furthermore, it wasn't Roman-armored figures stomping around in a so-called god-war. I think it helped that the story was set in the shadowy, bizarre 'world of magic', instead of Olympus or Paradise Island, ..and that she and Diana were the only Greek mythicals, in the story. For Circe, it was a classic outing...
And certainly makes a case for her taking 'archenemy' spot in the Wonder-rogues gallery.